Ing... Plce1 marker:rs2274223 this snp is in a gene called plce1, which encodes a protein called phospholipase c epsilon 1 that is involved in regulation of cell growth, differentiation, and cell death. The plce1 protein binds to the ras family of small proteins known to play a role in many cancers. viagra generic side effects Recent studies demonstrated involvement of plce1 in the development of skin and intestinal cancers as well as head and neck squamous cell carcinomas. Two recent studies independently found an association between rs2274223 and risk for esophageal squamous cell carcinoma (escc) in individuals from various regions in china. correct dosage viagra Escc is particularly prevalent in china and japan compared to western countries, with a combination of lifestyle and genetic factors likely accounting for the difference. generic viagra without prescription Both groups of researchers observed that the less common g version of rs2274223 conferred about 1. buy viagra canada 4 times higher odds of escc. The same two groups also investigated this snp in the context of a type of upper stomach cancer (gastric cardia adenocarcinoma, or gca) and found it to be associated with higher risk for that disease as well (see our report on stomach cancer (gastric cardia adenocarcinoma) for more details). viagra 20 mg prices Since the g version of rs2274223 causes an amino acid change in the plce1 protein it is possible that it affects the protein's function. Verification of this is still needed, but preliminary experiments showing that escc and gca tissues contain significantly more plce1 protein than normal tissues suggests a distinct role for plce1 in the development of esophageal and stomach cancer. This association has not been studied in populations with european or african ancestry. Citations wang ld (2010). viagra online “genome-wide association study of esophageal squamous cell carcinoma in chinese subjects identifies susceptibility loci at plce1 and c20orf54. viagra vs. viagra vs. viagra which is best ” nat. Genet. 42(9):759-63. Abnet cc (2010). viagra cost “a shared susceptibility locus in plce1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. ” nat. buy viagra without prescription Genet. 42(9):764-7. Parkin dm (2005). “global cancer statistics, 2002. ” ca cancer j clin 55(2):74-108. viagra 20 mg prices The genotyping services of 23andme are performed in labcorp's clia-certified laboratory. viagra 20 mg prices The tests have not been cleared or approved by the fda but have been analytically validated according to clia standards. viagra canada The information on this page is intended for research and educational purposes only, and is not for diagnostic use. Is now part of 23andme learn how patients are managing their healt.